Research Overview

These tiny molecules—including short-chain fatty acids, neurotransmitter precursors, and other bioactive compounds—can cross biological barriers and modulate brain function in surprising ways.

Understanding these interactions offers promising new avenues for promoting mental health and treating neurological disorders.

Current Questions We’re Exploring:

• Which microbial metabolites most strongly influence brain activity?

• How do these compounds interact with neural circuits involved in mood, memory, and cognition?

• Can dietary or probiotic interventions meaningfully shift metabolite profiles in ways that support brain health?

Methods We Use:

• Metabolomic profiling (mass spectrometry)

• Behavioral testing in animal models

• In vivo neuroimaging

• Electrophysiology

• Computational modeling of gut-brain signaling pathways

Why It Matters

Unraveling how gut microbes shape brain function could lead to innovative, non-invasive interventions for mental health challenges. We aim to translate basic science discoveries into actionable strategies that improve well-being across the lifespan.